The Cadillac V-16 (sometimes known as the Cadillac Sixteen) was Cadillac's top-of-the-line car from its January 1930 launch until production ceased in 1940 as the war in Europe killed sales. All were finished to custom order, and the car was built in very small numbers; only 4076 cars were constructed in the eleven years the model was offered. The majority of these were built in the single year of 1930, before the Great Depression really took hold. This was the first V16 powered car to reach production status in the United States.

The Fleetwood catalog for the 1930 V-16 included 10 basic body styles; there was also an envelope containing some 30 additional designer's drawings. Research by the Cadillac-La Salle Club, Inc. puts at 70 the number of different job/style numbers built by Fisher and Fleetwood on the sixteen chassis. The Series 452 from 1930 until 1937, a narrow 45° V angle OHV (overhead valve) engine that displaced 452 cubic inches (7.4 liters).