Facing the German invasion, in the autumn of 1941 the production line at Moscow plant was stopped and ZIS was moved to Ulyanovsk (on the Volga) and to Miass (in theChelyabinsk region of the Urals). Production at Ulyanovsk UASZIS lasted from February 1942 to 1944, while UralZIS at Ulyanovsk it began in July 1944; UralZIS fitted the truck radiators with own label and produced it until 1955, well after the end of the war.
In the meantime Moscow ZIS plant had restarted production of these trucks in April 1942, and continued until 1948, when the new ZIS-50 (ZIS-5 with new engine) appeared. In 1955 UralZIS also modified the ZIS-5: It got new engine and oval fenders, different from pre-war ones. This new model received the designation of UralZIS-355 or ZIS-355.